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Compound Overview
Urocortin II (human) TFA (CAS 398001-88-2) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 398001-88-2 |
|---|---|
| Molecular Formula | C196H340F3N63O56S |
| Molecular Weight | 4564.32 g/mol |
| SMILES | OC(=O)C(F)(F)F.CC(CH)(C)(CH)(N)C(=O)N(CH)(C(C)C)C(=O)N(CH)(CC(C)C)C(=O… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Urocortin II, a neuropeptide hormone within the corticotropin-releasing factor (CRF) familywhich comprises mammalian CRF, urocortin I, urocortin III, frog sauvagine, and piscine urotensin Idisplays 34, 43, and 37-40% sequence homology with rat and human CRF, human urocortin I, and human urocortin III, respectively. This compound enhances rabbit ventricular myocyte shortening and relaxation in both a time- and concentration-dependent manner. In vivo studies reveal that urocortin II lowers arterial blood pressure in both normotensive and spontaneously hypertensive rats through peripheral CRF2 receptor agonism, inducing dose-dependent tachycardia and hypotension at doses of 3 and 30 pmol/kg. Additionally, it mitigates the visceral pain response to colorectal distension at 10 and 20 ug/kg in conscious rats and delays gastric emptying in mice.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
It is not recommended to store DMSO stock solutions at room temperature. Once the stock solution is prepared, aliquot into single-use volumes and store at −20 °C (or −80 °C for sensitive compounds). Room-temperature storage accelerates chemical degradation and moisture uptake. When ready to use, thaw an aliquot at room temperature, use immediately, and avoid repeated freeze-thaw cycles.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
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