| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | ORY-2001 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Vafidemstat (CAS 1357362-02-7) is a research-grade small molecule supplied by TargetMol.
Alternative names: ORY-2001
Physical Properties
| CAS Number | 1357362-02-7 |
|---|---|
| Molecular Formula | C19H20N4O2 |
| Molecular Weight | 336.39 g/mol |
| SMILES | N(CC1=NN=C(N)O1)(CH)2(CH)(C2)C3=CC=C(OCC4=CC=CC=C4)C=C3 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Vafidemstat (ORY-2001) is a selective, orally active lysyl-histone demethylase (LSD1)/MAO-B inhibitor that crosses the blood-brain barrier for the study of neurological diseases.
Target(s): Histone Demethylase, MAO
Signaling pathway(s): Chromatin/Epigenetic, Metabolism, Neuroscience
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Centrifuge the closed vial at 3000 rpm for 1–2 minutes to consolidate the powder at the bottom. For electrostatically charged powders, briefly warm the vial to room temperature and allow it to equilibrate before opening. Then add the appropriate solvent directly onto the powder and vortex before sonicating. Avoid tapping the vial vigorously, as this can generate fine powder aerosol.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
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