Valerenic acid

Product details

• Chemical name: (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-Hexadydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoic acid
• Also known as: (-)-Valerenic Acid, (2E)-3-[(4S,7R,7aR)-3,7-dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl]-2-methylacrylic acid
• CAS number: 3569-10-6
• Molecular formula: C15H22O2
• Purity: >98% (HPLC)
• Concentration: 10 - 200 µM
• Form: Lyophilized Powder
• Solubility: Soluble in Ethanol and DMSO.Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
• Reconstitution: Soluble in Ethanol and DMSO.Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: GABAA receptor
• Source: Synthetic
• Activity: Valerenic acid is a positive allosteric modulator of GABAA receptors that displays preference for β2 or β3 subunit receptors. Directly activates the receptor and also blocks the channel at high concentrations. Displays an anxiolytic and sedative activity in vivo1-3. Also acts as a partial agonist of 5-HT5A receptors4.
• Alternative names: (-)-Valerenic Acid, (2E)-3-[(4S,7R,7aR)-3,7-dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl]-2-methylacrylic acid

Scientific background

Valerenic acid was first isolated in 1957 from the rhizome and roots of valerian (Valeriana offi-cinalis). Valerian is one of the oldest medicinal herbs in folk medicine and has been used for various afflictions like insomnia, anxiety, and pain. Valerenic acid was found to be pharmacologically active monoterpene acting through binding to the GABAA receptor1.Valerenic acid acts as an anti-inflammatory agent by inhibiting the transcription of NF-κB, one essential transcription factor controlling the expression of numerous inflammation-related genes. In addition, evidence suggests that Valerenic acid acts as an agonist for 5-HT receptors (serotonin receptors), which are G-coupled receptors that mediates neuronal activity via regulating cyclic adenosine monophosphate (cAMP) levels2.In-vivo studies that conducted on xenograft glioblastoma multiforme (GBM) mice models shown that Valerenic acid induce cell death of GBM cells by inducing AMPK activation. Therefore, Valerenic acid may serve as a potential anti-tumor agent towards GBM patients3.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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