| Field | Specification |
|---|---|
| Mfr No | |
| Accession Number | |
| Alternative Names | Voltage Dependent Anion Channel 1, Porin, Voltage dependent anion selective channel protein 1, Voltage-dependent anion-selective channel protein 1, hVDAC1, MGC111064, Mitochondrial Porin, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, PORIN-31-HL, VDAC 1, VDAC, VDAC-1 |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | Fusion protein amino acids 1-283 (full-length) of human VDAC1. Mouse: 98% identity (279/283 amino acids identical). Rat: 98% identity (279/283 amino acids identical) >60% identity with VDAC2 and VDAC3. |
| Isotype | |
| Product Type | |
| Reactivity | |
| Shipping | |
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| Target |
Voltage-dependent anion-selective channel protein 1 (VDAC1), also known as mitochondrial porin 1, is a pivotal protein embedded in the outer mitochondrial membrane. It serves as the primary gateway for the exchange of ions and metabolites between mitochondria and the cytosol, playing a critical role in cellular energy metabolism, calcium homeostasis, and apoptosis. VDAC1 also functions as a docking site for key regulatory proteins, including hexokinase and BCL2L1, linking mitochondrial activity to glycolysis and cell survival pathways.
In the context of neurodegenerative diseases, VDAC1 has emerged as a key player in mitochondrial dysfunction—a hallmark of disorders such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Its involvement in the formation of the mitochondrial permeability transition pore complex (PTPC) facilitates the release of pro-apoptotic factors, triggering neuronal cell death. Dysregulation of VDAC1 expression or function has been associated with increased oxidative stress, impaired bioenergetics, and neuroinflammation.
Given its central role in mitochondrial physiology and apoptosis, VDAC1 is increasingly recognized as a promising therapeutic target in neuroscience and neurodegeneration research. Understanding its molecular interactions and regulatory mechanisms may unlock new strategies for mitigating neuronal loss and preserving cognitive function.
1 µg/ml of SMC-456 was sufficient for detection of VDAC1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-456D — Size: 100 ug: VDAC1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-456D, RRID: AB_2701955)
- SMC-456D-A390 — Size: 100 ug: VDAC1 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-456D-A390, RRID: AB_2701956)
- SMC-456D-A488 — Size: 100 ug: VDAC1 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-456D-A488, RRID: AB_2701957)
- SMC-456D-A594 — Size: 100 ug: VDAC1 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-456D-A594, RRID: AB_2701959)
- SMC-456D-APC — Size: 100 ug: VDAC1 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-456D-APC, RRID: AB_2701965)
- SMC-456D-BI — Size: 100 ug: VDAC1 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-456D-BI, RRID: AB_2701966)
- SMC-456D-FITC — Size: 100 ug: VDAC1 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-456D-FITC, RRID: AB_2701967)
- SMC-456D-HRP — Size: 100 ug: VDAC1 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-456D-HRP, RRID: AB_2701968)
- SMC-456D-PCP — Size: 100 ug: VDAC1 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-456D-PCP, RRID: AB_2701970)
- SMC-456D-RPE — Size: 100 ug: VDAC1 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-456D-RPE, RRID: AB_2701971)
- SMC-456S — Size: 12 ug: VDAC1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-456S, RRID: AB_2701955)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
