| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | DMSO, methanol or acetone. |
| Source | Natural |
| Storage | |
| Target |
Product details
- Chemical name: 5H,12H-3,4-Dioxa-5a,11a,15atriazacyclooct(lm)indeno(5,6-b)fluorene-11,15(2H,13H)-dione,1,10,10a,14,14a,15b-hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-,(5R,10S,10aR,14aS,15bS).
- CAS number: 12771-72-1
- Molecular formula: C27H33N3O7.
- Purity: >98%
- Concentration: 10-100 nM.
- Form: Lyophilized Powder
- Solubility: DMSO, methanol or acetone.
- Reconstitution: DMSO, methanol or acetone.
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: KCa1.1 K+ channels
- Source: Natural
- Activity: Verruculogen is a selective blocker of KCa1.1 (BK) channel. It belongs to a set of tremorgenic indole alkaloids1.
Scientific background
Verruculogen is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Penitrem A (#P-650) and Paxilline (#P-450).2Verruculogen enhanced the electrically induced twitch contractions in guinea pig ileum, without influencing the contractions provoked by exogenous acetylcholine.1 Verruculogen had similar effects to Iberiotoxin (#STI-400) in inhibiting the early Ca2+ dependent K+ current in CA1 pyramidal cells.3
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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