| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Source | Plant — Myrtaceae Myrciaria dubia (Kunth) McVaugh |
| Molecular weight | |
| Molecular formula | C41H26O26 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Vescalagin, a hexahydroxyphenol, can be isolated from Camu-camu (Myrciaria dubia) and immature wax apple fruits. It inhibits a range of enzymes, with Ki values of 5.87 nM against AChE, 3.89 nM against BChE, 11.75 nM against hCA I, 16.23 nM against hCA II, and 16.08 nM against α-glucosidase, acting non-competitively at hCA I, hCA II and α-glucosidase. In methylglyoxal-treated rats it downregulates JNK/p38 MAPK to protect pancreatic β-cells and enhance insulin secretion, and it lowers hyperglycemia and hypertriglyceridemia in rats on a high-fructose diet; anti-inflammatory and antioxidant properties have also been reported[1].
It has the molecular formula C41H26O26 and a molecular weight of 934.63 g/mol.
Physical & Chemical Properties
| CAS Number | 36001-47-5 |
|---|---|
| Molecular Formula | C41H26O26 |
| Molecular Weight | 934.63 g/mol |
| Structure Classification | Phenols Polyphenols |
| SMILES | OC1=C(O)C(O)=C(C2=C3C=C(O)C(O)=C2O)C=C1C(OC[C@](OC(C4=C(C5=C6C(C7=C(C(O[C@@]8([H])[C@@H]9O)=O)C9=C(O)C(O)=C7O)=C(O)C(O)=C5O)C(O)=C(O)C(O)=C4)=O)([H])[C@@]([C@@H]8OC6=O)([H])OC3=O)=O |
| Target | AChE, BChE, hCA I, hCA II, α‑glucosidase |
| Signaling Pathway | Neuronal Signaling; Metabolic Enzyme/Protease; MAPK/ERK Pathway |
| Initial Source | Plant — Myrtaceae Myrciaria dubia (Kunth) McVaugh |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
AChE 5.87 nM (Ki) |
BChE 3.89 nM (Ki) |
hCA I 11.75 nM (Ki) |
hCA II 16.23 nM (Ki) |
α‑glucosidase 16.08 nM (Ki) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Gulcin İ, et al. Analytical profiling of vescalagin: Antioxidant Capacity and multi-enzyme inhibition spectrum[J]. Talanta Open, 2026, 13: 100624.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Vescalagin inhibits acetylcholinesterase (AChE) with a Ki of 5.87 nM[1]. Vescalagin inhibits butyrylcholinesterase (BChE) with a Ki of 3.89 nM[1]. Vescalagin is a non-competitive inhibitor of α-glucosidase (Ki = 16.08 nM)[1]. Vescalagin is a non-competitive inhibitor of hCA I (Ki = 11.75 nM)[1]. Vescalagin is a non-competitive inhibitor of hCA II (Ki = 16.23 nM)[1].
In Vivo
In rats treated with Methylglyoxal, Vescalagin protects pancreatic β-cells and improves insulin secretion by raising glutathione levels and antioxidant enzyme expression and by downregulating the JNK/p38 MAPK pathway[1]. In rats fed a high-fructose diet, Vescalagin lowers hyperglycemia and hypertriglyceridemia[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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