| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Vismodegib; 879085-55-9; GDC-0449; Erivedge; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691 |
| Cas No. | |
| Form | Off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (200 mg/ml); or ethanol (10 mg/ml, warm) |
| Source | Synthetic |
| Storage |
Vismodegib is a selective inhibitor of the Hedgehog signaling pathway via Smoothened (SMO) receptor antagonism. While primarily used in oncology, Vismodegib has emerging applications in neuroscience, particularly in studies of neural development, stem cell maintenance, and glioblastoma. Dysregulation of Hedgehog signaling has been implicated in neurodevelopmental disorders and brain tumors. Vismodegib is used to dissect the role of this pathway in neural stem cell proliferation, differentiation, and tumorigenesis.
GHS Classification: GHS08 health hazard
Repr. 2 H361 Suspected of damaging fertility or the unborn child.
STOT RE 2 H373 May cause damage to organs through prolonged or repeated exposure.
Signal word:
Warning
Hazard statements:
- H361 Suspected of damaging fertility or the unborn child.
- H373 May cause damage to organs through prolonged or repeated exposure.
Precautionary statements:
- P260 Do not breathe dust/fume/gas/mist/vapours/spray.
- P280 Wear protective gloves/protective clothing/eye protection/face protection.
- P308+P313 IF exposed or concerned: Get medical advice/attention.
- P314 Get medical advice/attention if you feel unwell.
- P405 Store locked up.
- P501 Dispose of contents/container in accordance with local/regional/national/international regulations.
Vismodegib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-565)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
