| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Voruciclib (CAS 1000023-04-0) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 1000023-04-0 |
|---|---|
| Molecular Formula | C22H19ClF3NO5 |
| Molecular Weight | 469.84 g/mol |
| SMILES | OC=1C(=C2C(C(=O)C=C(O2)C3=C(Cl)C=C(C(F)(F)F)C=C3)=C(O)C1)(CH)4(CH)(CO)… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the transcriptional regulator of MCL-1.
Target(s): CDK
Signaling pathway(s): Cell Cycle/Checkpoint
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
Determining the amount based on solution clarity.1. If the prepared solution is clear, it can be prepared in a larger amount for one-time use and stored at 4°C. It is recommended to prepare the solution once a week, as prolonged storage may lead to loss of efficacy. 2. If the prepared solution is a suspension, it is recommended to prepare and use immediately each time.
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