| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C23H24FN3O3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
VU6001192 is a potent, selective negative allosteric modulator of mGlu2 (metabotropic glutamate receptor 2), with potent inhibitory activity against the mGlu2 receptor (IC50 = 207 nM) but no activity against the mGlu3 receptor or the other six mGlu subtypes. It can be used for research on neurological disease, such as depression[1]. It has a molecular formula of C23H24FN3O3 and a molecular weight of 409.45 g/mol.
Physical & Chemical Properties
| CAS Number | 1821325-29-4 |
|---|---|
| Molecular Formula | C23H24FN3O3 |
| Molecular Weight | 409.45 g/mol |
| SMILES | O=C1C(C(N)=O)=CN(C2=CC=C(CN3C[C@H](O[C@H](C3)C)C)C=C21)C4=CC=C(C=C4)F |
| Target | mGlu2 Receptor |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
mGlu2 Receptor 207 nM (IC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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