| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline.
- CAS number: 155584-74-0
- Molecular formula: C13H15Cl2N4.
- Purity: >99%
- Concentration: 0.05 nM - 100 nM.
- Form: Lyophilized Powder
- Solubility: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: 5-Hydroxytryptamine Receptor 3A and 3B
- Source: Synthetic
- Activity: VUF 10166 is a potent and selective 5-HT3A and B receptor antagonist1.
Scientific background
VUF 10166 is a potent and selective antagonist of 5-HT3A and B receptors. It binds specifically and with high affinity to 5-HT3A (IC50 ~ 0.04 nM) and blocks the serotonin binding site. There's evidence of lower affinity to 5-HT3A/B receptors due to the influence of an additional allosteric binding site in the heteromer2.VUF 10166 is able to bind to an orthosteric binding site of HT3A and 5-HT3A/B receptors - A+A− and an A+B− interface. binding to the A+B− interface in the 5-HT3A/B receptor may decrease the affinity of ligands binding to the A+A− site by allosterically increasing the rate of ligand dissociation from the adjacent orthosteric site1,3.The 5-HT3 receptor subtype is a member of the Cys-loop ligand-gated cation channels which are expressed throughout the central and peripheral nervous systems and mediates a variety of physiological functions4.Competitive antagonists of 5-HT3 receptors are used to treat symptoms of emesis arising from chemotherapy treatment and postoperative emesis after anesthesia and surgery. There is also a limited use of antagonists for treating irritable bowel syndrome2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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