| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C46H53ClN10O5 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
WCA-814 is a conjugate of an androgen receptor (AR) antagonist and an Hsp90 inhibitor. It induces degradation of full-length AR and AR-V7, and shows cytotoxic effects in prostate cancer cells, with IC50 values of 171.2 nM in LNCaP cells and 26.5 nM in 22Rv1 cells[1]. It has a molecular formula of C46H53ClN10O5 and a molecular weight of 861.43 g/mol.
Physical & Chemical Properties
| CAS Number | 2951858-45-8 |
|---|---|
| Molecular Formula | C46H53ClN10O5 |
| Molecular Weight | 861.43 g/mol |
| SMILES | CC(C1=C(C=C(C(C2=NNC(N2C3=CC=C(C=C3)CN4CCN(CC4)CC5CCN(CC5)C6=CC=C(N=N6)C(N[C@H]7CC[C@@H](CC7)OC8=CC(Cl)=C(C=C8)C#N)=O)=O)=C1)O)O)C |
| Signaling Pathway | Vitamin D Related/Nuclear Receptor |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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