| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | WHI-P131, Janex 1, 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol |
| Cas No. | |
| Form | White to off-white solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml) |
| Source | Synthetic |
| Storage |
WHI P131, also known as Janex-1, is a potent, reversible, and selective inhibitor of Janus kinase 3 (JAK3). In neuroscience, WHI P131 is used to investigate the role of JAK3 signaling in neuroinflammation and glioblastoma progression. It has been shown to inhibit glioblastoma cell adhesion and migration, as well as thrombin-induced platelet aggregation. Given the involvement of JAK/STAT pathways in neuroimmune responses, WHI P131 is a valuable tool for studying neuroinflammatory mechanisms and potential therapeutic interventions in neurodegenerative diseases.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WHI P131 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-485)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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