| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C21H17BrN2O5 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Wnt pathway inhibitor 3 is a potent inhibitor of the Wnt pathway, with an IC50 value of 45 nM, and it shows antiproliferative activity[1]. It is supplied as a white to off-white solid (C21H17BrN2O5, MW 457.27) at 98.96% purity.
Physical & Chemical Properties
| CAS Number | 663213-98-7 |
|---|---|
| Molecular Formula | C21H17BrN2O5 |
| Molecular Weight | 457.27 g/mol |
| Purity | 98.96% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | N#CC1=C(N)OC2=C(C1C3=CC(Br)=C(C(OC)=C3)OCC=C)C=C4OCOC4=C2 |
| Signaling Pathway | Stem Cell/Wnt |
| Solubility | In Vitro: DMSO: 2 mg/mL (4.37 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 45 nM (wnt)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Michael Boutros, et al. Chromene derivatives and their analoga as wnt pathway antagonists. US20130296344A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 2 mg/mL (4.37 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Wnt pathway inhibitor 3 (0-100 000nM; 72 h) has antiproliferative activity, with IC50s of 641 nM (HS68), 470 nM (Dld1), 551 nM (HCT116), and 618 nM (SW480)[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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