| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C25H32N2O4S |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
WRR139 is a peptide vinyl sulfone linked to disease processes such as inflammation and cancer. It inhibits both cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1, and enhances the cytotoxicity of Carfilzomib against cancer cells[1]. It is supplied as a white to off-white solid (C25H32N2O4S, MW 456.60) at 99.71% purity.
Physical & Chemical Properties
| CAS Number | 2138924-36-2 |
|---|---|
| Molecular Formula | C25H32N2O4S |
| Molecular Weight | 456.60 g/mol |
| Purity | 99.71% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C(NCCC(C)C)[C@@H](NC(/C=C/S(C1=CC=C(C)C=C1)(=O)=O)=O)CCC2=CC=CC=C2 |
| Signaling Pathway | NF-κB; Metabolic Enzyme/Protease |
| Solubility | In Vitro: DMSO: 100 mg/mL (219.01 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (219.01 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2.5 mg/mL (5.48 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
In Vitro
WRR139 (0.01-100 μM; 1 h) inhibits NGLY1 in vitro and impairs Nrf1 processing in HEK293 cells[1]. In HEK293 cells, WRR139 (5 μM; 18 h) disrupts the processing, location, and activation of Nrf1[1]. In U266, H929, and Jurkat cells, WRR139 (1 μM; 24 h) increases the cytotoxicity of Carfilzomib in an NGLY1-dependent manner[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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The ameliorative role of phlorotannin on aflatoxin B1-induced liver oxidative stress and mitochondrial injury is related to the activation of Nrf2 and Nrf1 signaling pathways in broilers. J Anim Sci Biotechnol 2025 May 22;16(1):75. PMID: 40405298
ATF4 Coordinates Transcriptomic and Structural Adaptations in Aging Muscle. bioRxiv 2026 Mar 28:2026.03.27.711928. PMID: 41929138
bioRxiv. 2026 Jan 19.
