| Field | Specification |
|---|---|
| Alternative names | 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid, Pirinixic acid, 2-[4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl]sulfanylacetic acid, WY-14,643, WY14643, WY 14643, Wyeth 14,643 |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C14H14ClN3O2S |
| Purity | |
| Bioactivity | Agonist |
| Activity | |
| Solubility | Soluble in DMSO (40 mg/ml) |
| SMILES | |
| InChIKey | |
| Form | Off white powder |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
WY-14643 is a selective agonist of peroxisome proliferator-activated receptor alpha (PPARα), primarily studied in the context of lipid metabolism and inflammation. Although not widely cited in neurodegenerative disease research, its anti-inflammatory properties and ability to modulate oxidative stress pathways suggest potential relevance in neuroinflammation and neurodegeneration. WY-14643 may be explored for its capacity to regulate metabolic dysfunction and glial activation in neurological disorders.
Classification: D2B Toxic Material Causing Other Toxic Effects Moderate skin irritant - Moderate respiratory irritant, Moderate eye irritant
Hazard statement(s):
- H302 Harmful if swallowed.
- H315 Causes skin irritation.
- H319 Causes serious eye irritation.
- H335 May cause respiratory irritation.
- H350 May cause cancer.
Precautionary statement(s):
- P201 Obtain special instructions before use.
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P308 + P313 IF exposed or concerned: Get medical advice/ attention.
WY-14643 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-531)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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