| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| Cas No. | |
| Form | Off white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (25 mg/ml) |
| Source | Synthetic |
| Storage |
XAV939 is a small molecule inhibitor of tankyrase 1 and 2, enzymes that regulate the Wnt/β-catenin signaling pathway by promoting degradation of Axin. In neuroscience, XAV939 is used to modulate Wnt signaling, which plays a critical role in neurodevelopment, synaptic plasticity, and neurogenesis. Dysregulation of Wnt signaling has been linked to neurodegenerative diseases and psychiatric disorders. XAV939 provides a means to explore the therapeutic potential of Wnt pathway modulation in CNS disorders.
Classification: D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion
D2B Toxic Material Causing Other Toxic Effects Moderate eye irritant
Hazard statement(s):
- H301 Toxic if swallowed.
- H319 Causes serious eye irritation.
Precautionary statement(s):
- P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
XAV939 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-532)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
