| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone.
- CAS number: 122955-42-4
- Molecular formula: C26H20N2O.
- Purity: >95%
- Concentration: 0.1-300 µM.
- Form: Lyophilized powder.
- Solubility: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min).
- Reconstitution: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: KCNQ K+ channels
- Source: Synthetic
Scientific background
Voltage-gated K+ channels of the KCNQ family (KV7) are widely expressed in nerves and smooth muscles where their general role is to hyperpolarise the cell membrane and thereby dampen excitability1.XE991 is a potent and selective blocker of KCNQ voltage-gated K+ channels. It blocks KV7.2 + KV7.3 (KCNQ2 + KCNQ3)/M-currents (IC50 = 0.6 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM)1. Suppression of the M-current causes an increase in intrinsic excitability2. XE991 enhances acetylcholine release from rat brain slices (EC50 = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer's disease therapeutics2. It was demonstrated that XE991 enhances learning and memory in healthy mice3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Cited application(s)
Electrophysiology
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