| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 1'-pentylspiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one.
- CAS number: 912656-34-9
- Molecular formula: C21H21N4O.
- Purity: >99% (HPLC)
- Concentration: 1 nM - 10 µM.
- Form: Lyophilized powder.
- Solubility: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: NaV1.7 channels
- Source: Synthetic
- Activity: XEN907 is a NaV1.7 channel blocker with an IC50 value of 5 nM for the channel in its inactivated state1.
Scientific background
Voltage-gated sodium (NaV) channels contribute to physiological and pathophysiological electrical signaling in nerve and muscle cells. NaV1.7 is highly expressed on the axons of somatic afferent neurons and is thought to play an important role in the signaling of inflammatory pain.XEN907 is a synthetic blocker of NaV1.7 channels. It has an effective concentration of 1 nM - 10 μM and an IC50 of 5 nM for NaV1.7 in its inactive state. XEN907 is highly specific for NaV1.7 and at a concentration of 10 μM was not found to have significant activity against some 63 receptors and transporters examined1. XEN907 is not toxic and has favorable hepatocyte metabolic stability in humans and dogs, although inhibition of CYP3A4 was observed in a recombinant human enzyme assay. XEN907 has 97% plasma protein binding property in rat. XEN907 exhibits modest bioavailability of 13% and a T0.5 of 2.6±0.1 hours. XEN907 is extensively distributed when administered intravenously and has a clearing rate of 9.4±1.7 (L/h/kg)1.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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