| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Y-27632 dihydrochloride, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide . 2HCl |
| Cas No. | |
| Form | White to pale yellow powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (25 mg/ml), methanol (25 mg/ml), acetonitrile (<1 mg/ml), dioxan (<1 mg/ml), water (very soluble |
| Source | Synthetic |
| Storage |
Y 27632 is a highly potent and selective inhibitor of Rho-associated protein kinases ROCK1 and ROCK2. It functions as an ATP-competitive inhibitor and is cell-permeable. In neurodegenerative disease research, Y 27632 is widely used to study cytoskeletal dynamics, axonal regeneration, and neuronal survival. By inhibiting ROCK signaling, Y 27632 promotes neurite outgrowth and reduces apoptosis, making it a promising compound for therapeutic strategies targeting spinal cord injury, Parkinson’s disease, and other neurodegenerative conditions.
Classification: Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 4), H332
Acute toxicity, Dermal (Category 4), H312
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
Precautionary statements:
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P264 Wash skin thoroughly after handling.
- P270 Do not eat, drink or smoke when using this product.
- P271 Use only outdoors or in a well-ventilated area.
- P280 Wear protective gloves/ protective clothing.
- P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
- P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
- P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
- P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
- P322 Specific measures (see supplemental first aid instructions on this label).
- P330 Rinse mouth.
- P363 Wash contaminated clothing before reuse.
- P501 Dispose of contents/ container to an approved waste disposal plant.
Y 27632 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-486)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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