| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C25H27FN8OS |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
YK-2-69 is a highly selective inhibitor of DYRK2, with an IC50 value of 9 nM, and it specifically interacts with Lys-231 and Lys-234 of DYRK2. It can be used in research related to prostate cancer[1]. It is supplied as a white to light yellow solid (C25H27FN8OS, MW 506.60) at 99.44% purity.
Physical & Chemical Properties
| CAS Number | 2619846-89-6 |
|---|---|
| Molecular Formula | C25H27FN8OS |
| Molecular Weight | 506.60 g/mol |
| Purity | 99.44% |
| Appearance | Solid |
| Color | White to light yellow |
| SMILES | O=C(N1CCN(CC1)CC)C2=CN=C(NC3=NC(C4=CC5=C(N=C(N(C)C)S5)C=C4)=C(F)C=N3)C=C2 |
| Target | DYRK2 |
| Signaling Pathway | Protein Tyrosine Kinase/RTK |
| Solubility | In Vitro: DMSO: 5.83 mg/mL (11.51 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
|
DYRK2 9 nM (IC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 5.83 mg/mL (11.51 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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