| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide; BTP2 |
| Cas No. | |
| Form | Off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (40 mg/ml) |
| Source | Synthetic |
| Storage |
YM-58483 is a calcium release-activated calcium (CRAC) channel blocker that modulates mast cell responses and inhibits antigen-induced histamine release. It also exhibits potent T-cell antiproliferative activity. In neurodegenerative disease research, YM-58483 is explored for its ability to modulate immune cell activation and calcium signaling, which are implicated in neuroinflammation and neuroimmune interactions in disorders such as multiple sclerosis and Alzheimer’s disease.
Classification: Caution: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
YM-58483 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-606)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Law M., et al. (2001) Int. J. Biochem. Cell Biol. 43:1228-1239.
3. K Ohga et al. (2008) Int. Immunopharmacol. 8:1787-1792.
