| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 10 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione hydrochloride.
- CAS number: 154164-30-4
- Molecular formula: C11H8ClN5O4.
- Purity: >99%
- Concentration: 50 nM - 50 µM.
- Form: Lyophilized powder.
- Solubility: 10 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 5 min).
- Reconstitution: 10 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: AMPA receptors
- Source: Synthetic
- Activity: YM 90K hydrochloride is a selective AMPA receptor antagonist; Ki of 84 nM1.
Scientific background
YM 90K is a selective and potent AMPA receptor antagonist. YM 90K inhibits the binding of [3H] AMPA with a Ki value of 84 nM1.YM 90K has been reported to have neuroprotective effects in focal and global cerebral ischaemia models. However, high or moderate doses of YM 90K induce behavioral changes, including sedation, muscular hypotonia and ataxia. In addition, the effects of YM 90K are short-lived. In this context, YM 90K may be useful for the treatment of acute epileptic conditions such as status epilepticus. Moreover, it might prevent pathological neuronal plasticity resulting from status epilepticus, since it shows an antiepileptogenic effect and protects hippocampal neurons during kainate-induced generalized seizures.YM 90K could be clinically useful, since a low dose exhibits significant, although weak effects against kindling without detectable behavioral adverse effects2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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