| Field | Specification |
|---|---|
| Alternative names | N-Benzyloxycarbonyl-L-prolyl-L-prolinal |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H22N2O4 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Z-Pro-prolinal, also known as N-Benzyloxycarbonyl-L-prolyl-L-prolinal, is a specific, orally active prolyl endopeptidase (PREP) inhibitor, with an IC50 of 0.4 nM against porcine PREP[1][2][3]. It is supplied as a white to off-white solid (C18H22N2O4, MW 330.38) at 99.9% purity.
Physical & Chemical Properties
| CAS Number | 88795-32-8 |
|---|---|
| Molecular Formula | C18H22N2O4 |
| Molecular Weight | 330.38 g/mol |
| Purity | 99.9% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C[C@H]1N(C([C@H]2N(C(OCC3=CC=CC=C3)=O)CCC2)=O)CCC1 |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 0.4 nM (porcine PREP)[2]
Ki: 3.7 nM (PREP from bovine brain)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vivo
Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) (100 mg/kg; p.o.; once) raises septal vasopressin content in rats[3].
| Animal Model | Male Wistar rats[3] |
|---|---|
| Dosage | 100 mg/kg |
| Administration | Oral administration, once |
| Result | Significantly increased the septal arginine-vasopressin (AVP) content. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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