| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 4-amino-N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-2-methoxybenzamide hydrochloride.
- CAS number: 99617-34-2
- Molecular formula: C15H21Cl2N3O2.
- Purity: >98%
- Concentration: 0.3-300 nM.
- Form: Lyophilized powder.
- Solubility: 100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: 100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: 5-HT3, 5-HT4 receptors
- Source: Synthetic
- Activity: Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM)1.
Scientific background
Zacopride hydrochloride is a derivative of benzamide, described as a potent 5-HT3 receptor antagonist with 5-HT4 receptor agonistic properties. Zacopride is a recemic compound. Studies showed that the S(-) form has a higher binding affinity for central and peripheral 5-HT3 receptor compared to R(+) zacopride1. Ki values for 5-HT3 and 5-HT4 receptors are 0.38 nM and 373 nM respectively3.There is some evidence from animal behavioral experiments that 5-HT3 receptor antagonists may be useful as anxiolytics, antipsychotics, cognition-enhancers and anti-addictive agents. It has been reported from these models that the S(-) enantiomer is potent in animal models of psychosis whereas the R(+) enantiomer is more potent in anxiety models1.Zacopride has been shown to be an effective anti-emetic agent against the emesis induced by cytotoxins and radiation in dogs, cats, non-human primates and ferrets2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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