| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 20 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 7-chloro-2-(4-methoxy-2-methylphenyl)-3,5-dihydropyridazino[4,5-b]quinoline-1,4,10-trione.
- CAS number: 170142-20-8
- Molecular formula: C19H14ClN3O4.
- Purity: >99%
- Concentration: 50 nM - 1 µM.
- Form: Lyophilized powder.
- Solubility: 20 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
- Reconstitution: 20 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: NMDA receptors
- Source: Synthetic
- Activity: ZD 9379 is a NMDA receptor antagonist1.
Scientific background
ZD 9379 is a neuroprotective, soluble and potent antagonist of the N-methyl-D-aspartate (NMDA) receptor. The compound acts at the glycine site on the NMDA receptor. This site is used as a therapeutic target for acute focal ischemia. ZD 9379 has the ability to pass the blood brain barrier and reduce infract size and frequency in models of ischemic stroke1,2.The NMDA receptors are a ligand-gated ion channel which is widely distributed in the central nervous system (CNS) and plays an important role in a variety of cellular processes and brain functions such as, synaptic plasticity, addiction and stroke. NMDA receptors mediate physiological functions such as learning and memory formation. They also play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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