| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 1H-β-D-ribofuranosyl-2-pyrimidinone, NSC 309132, 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside, 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one, 4-deoxyuridine, NSC 309132, pyrimidin-2-one beta-D-ribofuranoside, pyrimidin-2-one beta-ribofuranoside, pyrimidin-2-one beta-ribofuranoside, (L)-isomer, pyrimidin-2-one ribonucleoside, zebularine, Pyrimidin-2-one ribonucleoside, Pyrimidin-2-one beta-ribofuranoside, Pyrimidin-2-one beta-D-ribofuranoside |
| Cas No. | |
| Form | White powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (20 mg/ml); or water (20 mg/ml) |
| Source | Synthetic |
| Storage |
Zebularine is a DNA methyltransferase (DNMT) inhibitor that induces DNA hypomethylation and reactivates silenced genes. In neurodegenerative disease research, Zebularine is used to explore the role of epigenetic modifications in neuronal plasticity, memory, and neuroinflammation. It is particularly relevant in studies of Alzheimer’s disease, where aberrant DNA methylation contributes to gene silencing and synaptic dysfunction. Zebularine’s stability and low toxicity make it a useful tool for investigating epigenetic therapies in the central nervous system.
WHMIS Classification: Not a hazardous substance or mixture.
GHS Classification: Not a hazardous substance or mixture.
Zebularine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-560)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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