| Field | Specification |
|---|---|
| Alternative names | KBP-7072 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C29H36N4O7 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Zifanocycline, also known as KBP-7072, is a semisynthetic, third-generation aminomethylcycline antibiotic that inhibits normal bacterial ribosome function. It shows broad-spectrum in vitro antibacterial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens, and is available in both oral and injectable formulations. It can be used to research acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections[1][2]. The compound has the molecular formula C29H36N4O7 and a molecular weight of 552.62 g/mol.
Physical & Chemical Properties
| CAS Number | 1420294-56-9 |
|---|---|
| Molecular Formula | C29H36N4O7 |
| Molecular Weight | 552.62 g/mol |
| SMILES | O[C@]12[C@](C[C@@]3([H])C(C(C4=C(O)C(CN5CC6C(C6)C5)=CC(N(C)C)=C4C3)=O)=C2O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Zifanocycline (KBP-7072) has MIC90 values of <1 μg/ml against a range of pathogens, among them typical and atypical pathogens linked to community-acquired bacterial pneumonia (CABP)[1].
In Vivo
KBP-7072 showed a linear PK profile in Sprague-Dawley (SD) rats, beagle dogs, and CD-1 mice after single oral and i.v. doses and multiple oral doses. Oral bioavailability ranged from 12% to 32%, mean time to maximum concentration (T max) from 0.5 to 4 h, and mean half-life from approximately 6 to 11 h. Compared with dosing in fasted animals, oral dosing in the fed state led to marked reductions in maximum plasma concentration (C max) and area under the concentration-time curve (AUC). Mean bound fractions of KBP-7072 in mouse, rat, dog, monkey, and human plasma were 77.5%, 69.8%, 64.5%, 69.3%, and 69.2%, respectively[1]. In a neutropenic murine pneumonia infection model, KBP-7072 shows potent, dose-dependent activity against selected S. aureus strains, both methicillin-susceptible (MSSA) and methicillin-resistant (MRSA), over the studied dose range (0.25 to 64 mg/kg/6 h)[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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In vitro Activity of the Novel Tetracyclines Derivative, Zifanocycline Against Mycobacterium abscessus. Infect Drug Resist 2025 Oct 4:18:5239-5247. PMID: 41069760
