| Field | Specification |
|---|---|
| Alternative names | ADS-007; ARO HIF2 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C737H972F20N211O349P43S8 |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Zifcasiran, also known as ADS-007 or ARO HIF2, is a synthetic double-stranded siRNA RNAi trigger. It selectively targets hypoxia-inducible factor-2α (HIF2α), interrupting downstream pro-oncogenic signaling in clear cell renal cell carcinoma (ccRCC), and it engages the cell's RNAi machinery to direct HIF2α (EPAS1) mRNA for degradation, reducing the amount of free HIF2α mRNA available for translation[1]. It has the molecular formula C737H972F20N211O349P43S8 (MW 20339.13).
Physical & Chemical Properties
| CAS Number | 2437257-11-7 |
|---|---|
| Molecular Formula | C737H972F20N211O349P43S8 |
| Molecular Weight | 20339.13 g/mol |
| Signaling Pathway | Epigenetics; Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
Tumorgrafts of ccRCC in nude mice take up Zifcasiran[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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