| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: N-[(2-chloro-6-fluorophenyl)methyl]-N-methyl-5-nitrothiophene-2-carboxamide.
- Also known as: ZINC09315614, Z26888283, N-[(2-chloro-6-fluorophenyl)methyl]-N-methyl-5-nitrothiophene-2-carboxamide
- PubChem CID: 17392877
- Molecular formula: C13H10ClFN2O3S.
- Purity: >98%
- Concentration: 0.1-10 µM.
- Form: Lyophilized Powder
- Solubility: Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).
- Reconstitution: Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: P2X7 receptors
- Source: Synthetic
- Activity: ZINC9315614 is a novel antagonist of the purinergic P2X7 receptors, shown to inhibit YoPro1 uptake and BzATP-induced Ca2+ responses in HEK-hP2X7 cells with IC50 of 0.8 µM and 3.2 µM, respectively1.
- Alternative names: ZINC09315614, Z26888283, N-[(2-chloro-6-fluorophenyl)methyl]-N-methyl-5-nitrothiophene-2-carboxamide
Scientific background
ZINC9315614 is a selective antagonist of purinergic P2X7 receptors. It binds to the ATP-binding pocket of P2X71. ZINC9315614 inhibits YoPro1 dye uptake and BzATP-induced Ca2+ responses in HEK-human P2X7 cells with IC50 value of 0.8 µM and 3.2 µM, respectively1.P2X receptors are cationic trimeric channel complexes that function as ATP-gated calcium-permeable and are considered to be an attractive therapeutic target. This family contains seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in various cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors can be found in almost all tissues1,2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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