ZM447439

ZM447439 is a potent and selective inhibitor of Aurora B kinase, a key regulator of mitosis. In neuroscience, ZM447439 is used to study cell cycle regulation in neural progenitor cells and the role of mitotic kinases in neurodevelopment and neurodegeneration. By inducing mitotic arrest and apoptosis, it provides insights into the mechanisms of neuronal cell cycle re-entry and its contribution to neurodegenerative diseases such as Alzheimer’s.

Classification: Not a hazardous substance or mixture.

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

ZM447439 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-489)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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