Nanodisc Membrane Proteins

Recombinant membrane proteins reconstituted in nanodiscs — a native-like lipid bilayer environment for functional, cryo-EM and binding studies.

Membrane proteinsNative lipid bilayerCryo-EM readyGPCRs & transporters

Other formats: Detergent micelle · VLP

Nanodisc: a membrane scaffold protein nanodisc placing the target protein in a native lipid bilayer

908 products

Product	Product Type	Application	Price	Status	ACTION
New Human LPAR4-Strep full length protein-synthetic nanodisc Target: LPAR4	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human MRGX4-Strep full length protein-synthetic nanodisc Target: MRGX4	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human MRGX1-Strep full length protein-synthetic nanodisc Target: MRGX1	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human MCHR1-Strep full length protein-synthetic nanodisc Target: MCHR1	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human LT4R2-Strep full length protein-synthetic nanodisc Target: LT4R2	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human LSHR-Strep full length protein-synthetic nanodisc Target: LSHR	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human LPAR3-Strep full length protein-synthetic nanodisc Target: LPAR3	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human LTB4R-Strep full length protein-synthetic nanodisc Target: LTB4R	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human MC5R-Strep full length protein-synthetic nanodisc Target: MC5R	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human LPAR2-Strep full length protein-synthetic nanodisc Target: LPAR2	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human MC3R-Strep full length protein-synthetic nanodisc Target: MC3R	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human MAS1L-Strep full length protein-synthetic nanodisc Target: MAS1L	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human HRH2-Strep full length protein-synthetic nanodisc Target: HRH2	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human HCAR2-Strep full length protein-synthetic nanodisc Target: HCAR2	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human KISSR-Strep full length protein-synthetic nanodisc Target: KISSR	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human HRH4-Strep full length protein-synthetic nanodisc Target: HRH4	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human HRH1-Strep full length protein-synthetic nanodisc Target: HRH1	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human HCAR3-Strep full length protein-synthetic nanodisc Target: HCAR3	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GRM8-Strep full length protein-synthetic nanodisc Target: GRM8	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human ILDR2-Strep full length protein-synthetic nanodisc Target: ILDR2	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human MC4R-Strep full length protein-synthetic nanodisc Target: MC4R	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GRPR-Strep full length protein-synthetic nanodisc Target: GRPR	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human HRH3-Strep full length protein-synthetic nanodisc Target: HRH3	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human HCRTR1-Strep full length protein-synthetic nanodisc Target: HCRTR1	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human MBP-TRPV1-Strep full length protein-synthetic nanodisc Target: TRPV1	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View
New Human MLC1-Strep full length protein-synthetic nanodisc Target: MLC1	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human LGR5-Strep full length protein-synthetic nanodisc Target: LGR5	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human MRGPRX2-Strep full length protein-synthetic nanodisc Target: MRGPRX2	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human MFSD13A-Strep full length protein-synthetic nanodisc Target: MFSD13A	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human LGR4-Strep full length protein-synthetic nanodisc Target: LGR4	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human LGR6-Strep full length protein-synthetic nanodisc Target: LGR6	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human MBP-GPR75 full length protein-synthetic nanodisc Target: GPR75	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View
New Human MBP-AGTR1 full length protein-synthetic nanodisc Target: AGTR1	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View
New Human MDR-1-Strep full length protein-synthetic nanodisc Target: MDR-1	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human MBP-CLDN6 full length protein-synthetic nanodisc Target: CLDN6	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View
New Human KISSR full length protein-synthetic nanodisc Target: KISSR	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View

About Nanodisc Membrane Proteins

Nanodiscs wrap a single membrane protein in a small disc of native lipid bilayer held by two membrane scaffold proteins, keeping the target water-soluble while preserving a near-native lipid environment. This collection lists recombinant membrane proteins supplied pre-reconstituted in nanodiscs.

Choosing a membrane-protein format: Nanodisc vs Detergent vs VLP

Every product here is supplied in a nanodisc. Here is how that choice compares with the two other formats we stock, so you can confirm it fits your experiment.

Consideration	Nanodisc	Detergent micelle	VLP
Lipid environment	Native lipid bilayer disc	Detergent shell (lipids removed)	Native membrane on a capsid
Native function preserved	High	Variable — often reduced for GPCRs	High (keeps oligomeric state)
Best structural method	Single-particle cryo-EM	X-ray crystallography / LCP	Not for high-resolution structure
Display / valency	Monomeric, defined stoichiometry	Monomeric	Multivalent — many copies per particle
Typical particle	~9–13 nm disc	Protein–detergent micelle	~100 nm engineered capsid
Best for	Function + cryo-EM, SPR / BLI binding	Broad selection, high-res X-ray, cost	Immunization, antibody discovery, vaccines
Watch-outs	Disc size caps very large complexes	May alter GPCR conformation / stability	Less suited to atomic-resolution structure

How to read this: if you need the protein to behave as it does in a cell — ligand binding, channel gating, GPCR pharmacology — and you are heading toward cryo-EM, the nanodisc format is usually the right starting point. Choose detergent when you need the broadest selection or high-resolution X-ray, and VLPs when multivalent, native-oligomeric display matters (for example, raising antibodies).